Pharmaceutical Formulation Research
Evaluated as a water-soluble trimethylated chitosan derivative in experimental mucoadhesive, polymer-complex and delivery-system research.
Learn moreQCH-BSF
Quaternary Chitosan – (Mushroom)
Mushroom Origin Trimethylated Quaternary Chitosan for Formulation Research
Black Soldier Fly
Mushroom Quaternary Chitosan is a mushroom-derived, permanently cationic biopolymer with enhanced water solubility for advanced formulation and material development.
- Derived from mushroom chitosan
- Permanent positive charge from quaternary ammonium groups
- Enhanced water solubility compared with native chitosan
- Suitable for antimicrobial coating development
- Useful for cosmetic, textile, and industrial formulations
- Supports medical and pharmaceutical research
Synonyms: Quaternary Chitosan; N,N,N-Trimethylated Chitosan Derivative; Trimethylated Chitosan; TMC-Type Quaternary Chitosan; Cationic Chitosan Derivative; Water-Soluble Quaternized Chitosan
- Chemical identity
- N,N,N-Trimethylated Chitosan Derivative
- Average molecular weight
- 293 kDa
- Appearance
- White to pale-yellow powder
- Water solubility
- Freely soluble
- Degree of quaternization
- ≥45%; COA result: 52.2%
Properties
| Property | Value | Test method | Note |
|---|---|---|---|
| Chemical identity | N,N,N-Trimethylated Chitosan Derivative | Per manufacturer COA | Quaternary chitosan/TMC-type derivative |
| Average molecular weight | 293 kDa | Per manufacturer COA | Manufacturer identifies molecular weight as customizable |
| Appearance | White to pale-yellow powder | Visual inspection | COA result: Pale yellow |
| Water solubility | Freely soluble | Per manufacturer COA | COA result: Passes |
| Degree of quaternization | ≥45%; COA result: 52.2% | Per manufacturer COA | Key functional parameter |
| Purity on dry basis | ≥95%; COA result: 99.23% | Per manufacturer COA | Batch QCh/01/2025 |
| Viscosity | 1–10 cP; COA result: 1.8 cP | 1% solution at 25°C | |
| pH | 4.5–7.0; COA result: 5.2 | 1% aqueous solution |
Packaging & Quality
| Item | Detail |
|---|---|
| Sample packaging | A 25 g sample pack is available for preliminary formulation, compatibility and process evaluation. |
| Standard packaging | Standard 1 kg quantities are supplied in sealed, moisture-resistant packaging; confirm the container format before ordering. |
| Quality verification | The supplied COA reports identity, molecular weight, appearance, solubility, degree of quaternization, purity, viscosity, pH, residue on ignition, heavy metals and microbial count. |
| Source verification | Request a current manufacturer declaration when Black Soldier Fly origin or shellfish-free status is required for product claims. |
Tiered Pricing
| Quantity | Price / quote | Packaging | Shipping |
|---|---|---|---|
| 1–99 kg | $175/kg | 1 kg packs or commercial packaging | Tariff and shipping calculated separately |
| 100–499 kg | $160/kg | Commercial bulk packaging | Freight and applicable charges quoted separately |
| 500–999 kg | $145/kg | Commercial bulk packaging | Freight and applicable charges quoted separately |
| 1,000 kg or more | Request Quote | Custom bulk packaging | Custom freight and applicable charges quoted separately |
Product Overview
Applications
Cosmeceutical Formulation Research
Investigated as a cationic polymer in experimental hair-care, skincare, film-forming and surface-conditioning formulations.
Learn moreAgricultural Formulation Research
Evaluated in experimental coating, delivery and plant-treatment systems; crop-specific compatibility and performance testing are required.
Learn moreFiber and Textile Development
Studied as a cationic chitosan derivative for experimental fiber finishing, surface modification and bicomponent-material development.
Learn moreCationic Coating Research
Evaluated in experimental films, coatings and polymer systems where interaction with negatively charged substrates is required.
Learn moreDirections for Use
Storage and Handling
Keep the container tightly sealed in a cool, dry and well-ventilated area. Protect from moisture, direct sunlight and excessive heat. Avoid generating airborne dust and use appropriate laboratory or industrial hygiene practices.
Documentation
PDF
Download PDFCertificate of Analysis (COA)
Certificate of Analysis for Quaternary Chitosan identified as an N,N,N-trimethylated chitosan derivative, batch QCh/01/2025. The material had an average molecular weight of 293 kDa and was reported as a pale-yellow, odorless powder that passed the water-solubility test. The degree of quaternization was 52.2%, purity on a dry basis was 99.23%, viscosity was 1.8 cP in a 1% solution at 25°C, pH was 5.2 in a 1% aqueous solution, and residue on ignition was 0.42%. Heavy metals as lead were reported as NIL, and microbial count was below 100 CFU/g. The manufacturer states that the batch conforms to its specifications for pharmaceutical, agricultural and cosmeceutical-grade quaternized chitosan.
PDF
Material Safety Data Sheet / Safety Data Sheet
Document pending. Please contact us if you need this document before ordering.
Protocols and Articles
Trimethyl Chitosan for Oral Drug Delivery
Technical overview of trimethyl chitosan as a water-soluble quaternized derivative studied in experimental mucoadhesive and oral-delivery systems.
Quaternary Chitosan for Antimicrobial Systems
Reviews fixed-cationic chitosan chemistry and the factors that influence experimental coating, hydrogel and antimicrobial-material performance.
Peer-Reviewed Papers
Quaternary Ammonium Chitosans: The Importance of the Positive Fixed Charge
Fabiano A. et al. review how fixed positive charge influences the structure, solubility and investigated pharmaceutical properties of quaternary ammonium chitosans.
Chitosan and Its Derivatives as Intestinal Absorption Enhancers
Thanou M. et al. discuss chitosan derivatives, including trimethyl chitosan, in relation to solubility at neutral pH and experimental mucosal drug-delivery research.
Frequently Asked Questions
What type of quaternary chitosan is this product?
The manufacturer’s COA identifies the product as an N,N,N-trimethylated chitosan derivative. It is therefore a TMC-type quaternary chitosan rather than HTCC or HACC.
Is this product the same as HTCC?
No. The supplied COA identifies an N,N,N-trimethylated chitosan derivative. HTCC is a different quaternized structure commonly described as hydroxypropyl trimethyl ammonium chloride chitosan.
Is this quaternary chitosan water-soluble?
The batch COA specifies the material as freely soluble in water and records a passing solubility result. Compatibility should still be tested under the intended formulation conditions.
Is this material approved for pharmaceutical use?
The manufacturer states that the batch conforms to its pharmaceutical, agricultural and cosmeceutical specifications. This does not establish regulatory approval for a finished pharmaceutical product. Application-specific testing and regulatory review remain the buyer’s responsibility.
What should be checked before formulation scale-up?
Confirm the derivative identity, biological origin, current COA, solubility, degree of quaternization, molecular weight, viscosity, compatibility, safety documentation and regulatory requirements. Conduct laboratory and pilot-scale testing before commercial production.
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